import re
text = "Hello, world. I'm a boy, you're a girl."
replaced = re.sub('\S+', lambda m: re.sub('^\W+|\W+$', '', m.group()), text)
print(replaced)
aW1wb3J0IHJlICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIAoKdGV4dCA9ICJIZWxsbywgd29ybGQuIEknbSBhIGJveSwgeW91J3JlIGEgZ2lybC4iCnJlcGxhY2VkID0gcmUuc3ViKCdcUysnLCBsYW1iZGEgbTogcmUuc3ViKCdeXFcrfFxXKyQnLCAnJywgbS5ncm91cCgpKSwgdGV4dCkKcHJpbnQocmVwbGFjZWQp