import re
phrases = [ "S/O अशोक कुमार, ब्लॉक न.-4डी, S/O Ashok Kumar, Block no.-4D.", "स्ट्रीट-15, विभाग 5. सिविक सेंटर Street-15, sector -5, Civic Centre", "भिलाई, दुर्ग, भिलाई, छत्तीसगढ़, Bhilai, Durg. Bhilai, Chhattisgarh,", ]
rx = re.compile(r'.*[^\W\d_A-Za-z]\W*|\W+$')
l = [rx.sub('', text) for text in phrases]
print(l)

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