import re
p = re.compile(r'(?s)^.*?\s(\d+:\d+).*')
uptime = "22:59:49 up 109:32, 7 users, load average: 0.10, 0.02, 0.05"
print(p.sub(r"\1", uptime))
aW1wb3J0IHJlCnAgPSByZS5jb21waWxlKHInKD9zKV4uKj9ccyhcZCs6XGQrKS4qJykKdXB0aW1lID0gIjIyOjU5OjQ5IHVwICAxMDk6MzIsICA3IHVzZXJzLCAgbG9hZCBhdmVyYWdlOiAwLjEwLCAwLjAyLCAwLjA1IgpwcmludChwLnN1YihyIlwxIiwgdXB0aW1lKSk=