import re
line = ' 2501 12345678910 12345678910 40m Test Content\t Here. SMxx x x x x x x x'
rx = re.compile(r'^((?:[^\t\n]*\t){3})(.*?)(?=\t\s*SM)')
print(rx.sub(lambda x: f"{x.group(1)}{x.group(2).replace(chr(9), '<TAB WAS HERE>')}", line))
aW1wb3J0IHJlCmxpbmUgPSAnICAgIDI1MDEJMTIzNDU2Nzg5MTAJMTIzNDU2Nzg5MTAJNDBtIFRlc3QgQ29udGVudFx0IEhlcmUuCVNNeHggIHggeCB4IHggeCB4IHgnCnJ4ID0gcmUuY29tcGlsZShyJ14oKD86W15cdFxuXSpcdCl7M30pKC4qPykoPz1cdFxzKlNNKScpCnByaW50KHJ4LnN1YihsYW1iZGEgeDogZiJ7eC5ncm91cCgxKX17eC5ncm91cCgyKS5yZXBsYWNlKGNocig5KSwgJzxUQUIgV0FTIEhFUkU+Jyl9IiwgbGluZSkp