import re
message = 'Hello(/ how{can} wan\';t //opperate+32.5 u&# kj|'
print( re.sub(r'(\d+(?:[,.]\d+)+)|[\W_]+', lambda x: x.group(1) if x.group(1) else ' ', message).strip() )
aW1wb3J0IHJlCm1lc3NhZ2UgPSAnSGVsbG8oLyBob3d7Y2FufSB3YW5cJzt0IC8vb3BwZXJhdGUrMzIuNSB1JiMga2p8JwpwcmludCggcmUuc3ViKHInKFxkKyg/OlssLl1cZCspKyl8W1xXX10rJywgbGFtYmRhIHg6IHguZ3JvdXAoMSkgaWYgeC5ncm91cCgxKSBlbHNlICcgJywgbWVzc2FnZSkuc3RyaXAoKSAp