#!/bin/bash
s='aaaa:bbbb:cccc:dddd
eeee:ffff:gggg:hhhh
iiii:jjjj:kkkk:llll'
passwd='newpass'
lineNumber=2
sed -E "${lineNumber} s/^(([^:]*:){2})[^:]*/\1${passwd}/" <<< "$s"
IyEvYmluL2Jhc2gKcz0nYWFhYTpiYmJiOmNjY2M6ZGRkZAplZWVlOmZmZmY6Z2dnZzpoaGhoCmlpaWk6ampqajpra2trOmxsbGwnCnBhc3N3ZD0nbmV3cGFzcycKbGluZU51bWJlcj0yCnNlZCAtRSAiJHtsaW5lTnVtYmVyfSBzL14oKFteOl0qOil7Mn0pW146XSovXDEke3Bhc3N3ZH0vIiA8PDwgIiRzIg==