import hashlib

in_data = "0450863AD64A87AE8A2FE83C1AF1A8403CB53F53E486D8511DAD8A04887E5B23522CD470243453A299FA9E77237716103ABC11A1DF38855ED6F2EE187E9C582BA6".decode('hex')

my_sha = hashlib.sha256()

my_sha.update(in_data)

output = my_sha.digest().encode('hex')

print output