set.seed(1)
data <- data.frame(date = seq(from = ISOdatetime(2012, 01, 01, 00, 00, 00),
                              length.out = 4320, by=5),
                   nox = sample(1:20, 4320, replace=TRUE))

hr.means <- aggregate(data["nox"], 
                      list(hour = cut(data$date, breaks="hour")), 
                      mean, na.rm = TRUE)
hr.means