from win32com.client import Dispatch

excel = Dispatch("Excel.Application")
excel.Visible = 1
excel.Workbooks.Add()
excel.ActiveSheet.Cells(1,1).Value = "Hola SQLeros"
excel.ActiveSheet.Cells(1, 1).ClearComments()
excel.ActiveSheet.Cells(1, 1).AddComment()
excel.ActiveSheet.Cells(1, 1).Comment.Text(Text = 'Comentario generado por sqleros.com.ar')
excel.ActiveWorkbook.SaveAs("pruebaSQLeros.xls")
excel.Quit()