import re
s = "a,s I walk, I hum."
# Capturing group / backreference
print(re.sub(r"([aeiou]),", r"\1", s))
# Positive lookbehind
print(re.sub(r"(?<=[aeiou]),", "", s))
aW1wb3J0IHJlCnMgPSAiYSxzIEkgd2FsaywgSSBodW0uIgoKIyBDYXB0dXJpbmcgZ3JvdXAgLyBiYWNrcmVmZXJlbmNlCnByaW50KHJlLnN1YihyIihbYWVpb3VdKSwiLCByIlwxIiwgcykpCgojIFBvc2l0aXZlIGxvb2tiZWhpbmQKcHJpbnQocmUuc3ViKHIiKD88PVthZWlvdV0pLCIsICIiLCBzKSkK